PDB:1GT0

Protein Name

Oct4/Sox2/DNA complex

Species

Mouse, Human

Biological Context

Oct4 and Sox2 are transcription factors that direct development of the mammalian embryo. Recently, Yamanaka and co-workers have shown that induced pluripotent stem (iPS) cells can be generated using four transcription factors: Oct3/4, Sox2, Klf4, and c-Myc.

Structure Description

Oct4 consists of two POU (POU_H and POU_S) all-alpha globular domains that bind to the major groove of double-stranded DNA and are connected by a flexible linker. Sox4 is a single (HMG) domain all-alpha protein and binds to the terminal end of the DNA and also interacts with the larger (POU_S) domain.

Protein Data Bank (PDB)

PDB Summary: 1gt0
View Structure (jV4)

References

Source

Remenyi, A. Scholer, H.R. Wilmanns, M.; "Crystal Structure of a POU/Hmg/DNA Ternary Complex"; To be Published; () :-.

Others

UniProt:P14859 Oct1
UniProt:P48432 Sox4

author: Daron Standley

Japanese version:PDB:1GT0