Human rhinovirus 14 coat protein
Human rhinovirus 14 (human common cold virus)
"When you visit a doctor, a cold will last a week, when you do not treat it, it will last seven days" is often said when talking about the cold, a very frequent, mostly harmless, viral disease, which is why it is often referred to as the "Common Cold". In other words, there is no known effective cure for the common cold. Like other viruses of its class rhinovirus is an icosahedral virus with an approximately spherical shape of about 300 A in diameter. The capsid consists of 20 equilateral triangular faces, each corner of a face occupied by a complex of 4 viral proteins. There are therefore 60 copies of each viral protein in the capsid and 240 proteins in total. The interior of the capsid contains single-stranded RNA as the genetic material of the virus. This makes it a retrovirus, that means, host cells have to create DNA from this RNA for reproduction of the virus. While there may be no cure for the common cold yet, hope is that studying the structure of the virus might help to find one. Such is indeed the case.
Protein Data Bank (PDB)
author: Arno Paehler